⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915558 | 0.73 | — | — | |
| SCHEMBL456665 | 0.68 | — | — | |
| SCHEMBL10296433 | 0.67 | — | — | |
| SCHEMBL380295 | 0.66 | — | — | |
| SCHEMBL8125645 | 0.65 | — | — | |
| SCHEMBL12849111 | 0.62 | — | — | |
| SCHEMBL5232264 | 0.62 | — | — | |
| SCHEMBL1050915 | 0.62 | — | — | |
| SCHEMBL8583498 | 0.62 | — | — | |
| SCHEMBL7937744 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017103058-A1 | METHODS FOR THE PREPARATION OF 1,3-BENZODIOXOLE HETEROCYCLIC COMPOUNDS | LEO PHARMA A/S (DK) | 2017-06-22 | — | — | WO | disclosed |
| EP-2114951-B9 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2015-09-02 | — | — | EP | disclosed |
| EP-2248799-B1 | PROCESS FOR PREPARING 2-(SUBSTITUTED PHENYL)-2-HYDROXY-ETHYL CARBAMATES | SK BIOPHARMACEUTICALS CO LTD (KR) | 2015-05-20 | — | — | EP | disclosed |
| US-8338431-B2 | Phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2012-12-25 | — | — | US | disclosed |
| EP-2248799-A1 | Process for preparing 2-(substituted phenyl)-2-hydroxy-ethyl carbamates | Ortho-McNeil Pharmaceutical, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| US-20100099688-A1 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2010-04-22 | — | — | US | disclosed |
| EP-2114951-A2 | NOVEL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2009-11-11 | — | — | EP | disclosed |
| WO-2009117278-A2 | PROCESSES FOR PREPARING (AMINO-PYRAZOLOPYRIDINYL)METHOXY SUBSTITUTED BIARYL ETHERS | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |
| WO-2008104175-A2 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2008-09-04 | — | — | WO | disclosed |
| EP-0941998-B1 | 3,6-ketal macrolide antibiotics | PFIZER PROD INC (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-0786462-B1 | DC107 derivatives | KYOWA HAKKO KOGYO KK (JP) | 2002-09-18 | — | — | EP | disclosed |
| US-6043226-A | TREATING BACTERIAL, PARASITIC AND PROTOZOAL INFECTIONS | PFIZER INC. (US) | 2000-03-28 | — | — | US | disclosed |
| EP-0941998-A2 | 3,6-ketal and enol ether macrolide antibiotics | Pfizer Products Inc. (US) | 1999-09-15 | — | — | EP | disclosed |
| US-5733924-A | BACTERICIDES AND ANTITUMOR AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1998-03-31 | — | — | US | disclosed |
| EP-0786462-A1 | DC107 DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |