Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | CTSA | P10619 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | FABP1 | P07148 | 1/20 | 0.32 |
| ▸ | SDHB | P21912 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | STAT1 | P42224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29594311 | 1.00 | MAPK14 (0.36) | MAPK14CTSABRD4PTGS2RXFP1 | |
| SCHEMBL28899979 | 0.89 | MAPK14 (0.39) | MAPK14CTSABRD4PTGS2RXFP1 | |
| SCHEMBL29593255 | 0.89 | MAPK14 (0.39) | MAPK14CTSABRD4PTGS2RXFP1 | |
| SCHEMBL27806131 | 0.85 | MAPT (0.35) | MAPK14PTGS2SDHBKDM4EMITF | |
| SCHEMBL29593738 | 0.85 | MAPT (0.35) | MAPK14PTGS2SDHBKDM4EMITF | |
| SCHEMBL1064841 | 0.83 | HSP90AB1 (0.44) | MAPK14CTSARXFP1HDAC9ABL1 | |
| SCHEMBL28461712 | 0.82 | KCNH2 (0.37) | MAPK14BRD4PTGS2CDK2ABL1 | |
| SCHEMBL29594254 | 0.82 | KCNH2 (0.37) | MAPK14BRD4PTGS2CDK2ABL1 | |
| SCHEMBL29593211 | 0.82 | PTGS2 (0.37) | MAPK14BRD4PTGS2RXFP1SDHB | |
| SCHEMBL28464519 | 0.82 | PTGS2 (0.37) | MAPK14BRD4PTGS2RXFP1SDHB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114748622-A | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD | 弗尔康医疗公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-114732910-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-111601593-B | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-111601593-A | P38 kinase inhibitor reduces DUX4 and downstream gene expression for treatment of FSHD | 弗尔康医疗公司 | 2020-08-28 | — | — | CN | disclosed |