Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of 2-Chlorophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.75 |
| ▸ | TSHR | P16473 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Chlorophenol SCHEMBL28928152 | 0.89 | ALDH1A1 (0.60) | ALDH1A1TSHRLMNASMN1; SMN2IDO1 | |
| 2-Chlorophenol SCHEMBL28443588 | 0.89 | ALDH1A1 (0.60) | ALDH1A1TSHRLMNASMN1; SMN2IDO1 | |
| 2-Chlorophenol SCHEMBL29092797 | 0.89 | ALDH1A1 (0.60) | ALDH1A1TSHRLMNASMN1; SMN2IDO1 | |
| 2-Chlorophenol SCHEMBL12279 | 0.87 | — | — | |
| 2-Chlorophenol SCHEMBL8961529 | 0.87 | ALDH1A1 (1.00) | ALDH1A1TSHRLMNASMN1; SMN2HTT | |
| 2-Chlorophenol SCHEMBL29354452 | 0.87 | — | — | |
| 2-Chlorophenol SCHEMBL28038973 | 0.85 | ALDH1A1 (0.75) | ALDH1A1TSHRLMNASMN1; SMN2HSD17B10 | |
| 2-Chlorophenol SCHEMBL5444110 | 0.84 | — | — | |
| 2-Chlorophenol SCHEMBL7389931 | 0.84 | — | — | |
| 2-Chlorophenol SCHEMBL10882437 | 0.84 | ALDH1A1 (0.94) | ALDH1A1TSHRLMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117046026-A | Chemical coolant and application thereof in aerosol fire extinguishment | 湖北及安盾消防科技有限公司 | 2023-11-14 | — | — | CN | claimed |
| CN-117046026-A | Chemical coolant and application thereof in aerosol fire extinguishment | 湖北及安盾消防科技有限公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-103751943-B | Fire extinguishing composition containing nitrogen-containing organic compound | 湖北及安盾消防科技有限公司 | 2020-10-13 | — | — | CN | disclosed |