SCHEMBL28465796

SCHEMBL28465796

Nc1cccccc2ccccccc1-2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 1.00
HSD17B10 Q99714 3/20 1.00
L3MBTL1 Q9Y468 1/20 0.67
SMN1; SMN2 Q16637 2/20 0.50
HPGD P15428 2/20 0.50
CYP3A4 P08684 2/20 0.50
ALOX15 P16050 1/20 0.50
CASP1 P29466 1/20 0.50
CASP7 P55210 1/20 0.50
KDM4E B2RXH2 1/20 0.50
NPC1 O15118 1/20 0.50
GAA P10253 1/20 0.50
RAB9A P51151 1/20 0.50
ADORA3 P0DMS8 1/20 0.48
DPP4 P27487 1/20 0.48
BCL2L1 Q07817 1/20 0.48
CYP2A6 P11509 1/20 0.48
MAPK1 P28482 1/20 0.48
TAAR1 Q96RJ0 1/20 0.46
TDP1 Q9NUW8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25981 1.00 ALDH1A1 (1.00) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2HPGD
Benzene SCHEMBL28328298 1.00 ALDH1A1 (1.00) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2HPGD
SCHEMBL29407079 1.00 ALDH1A1 (1.00) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2HPGD
SCHEMBL27950997 1.00 ALDH1A1 (1.00) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2HPGD
Water SCHEMBL5177338 0.97 ALDH1A1 (0.94) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2HPGD
Water SCHEMBL11160127 0.97 ALDH1A1 (0.94) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2HPGD
Biphenyl SCHEMBL10703079 0.97 ALDH1A1 (0.94) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2HPGD
SCHEMBL30985618 0.97 ALDH1A1 (0.94) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2HPGD
SCHEMBL20819726 0.97 ALDH1A1 (0.94) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2HPGD
Hydrogen Sulfide SCHEMBL11811623 0.97 ALDH1A1 (0.94) ALDH1A1HSD17B10L3MBTL1SMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111867638-A Radiolabeled oligonucleotides and methods of making same 豪夫迈·罗氏有限公司 2020-10-30 CN disclosed