Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.57 |
| ▸ | RAF1 | P04049 | 6/20 | 0.57 |
| ▸ | KDR | P35968 | 9/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28900928 | 0.88 | BRAF (0.70) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL28473758 | 0.86 | KDR (0.59) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL28979425 | 0.85 | BRAF (0.56) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL30447912 | 0.85 | BRAF (0.56) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL28464544 | 0.84 | BRAF (0.51) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL30447715 | 0.84 | KDR (0.71) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL30448158 | 0.83 | MET (0.65) | BRAFRAF1KDRPDGFRAMET | |
| SCHEMBL30447998 | 0.83 | BRAF (0.57) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL30448378 | 0.83 | BRAF (0.72) | BRAFRAF1KDRMAPK14TNNI3K | |
| SCHEMBL30448305 | 0.83 | BRAF (0.61) | BRAFRAF1KDRMAPK14TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825605-B | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-03-31 | — | — | CN | disclosed |
| CN-111825605-A | Aryl ketone amide compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2020-10-27 | — | — | CN | disclosed |