Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.68 |
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.59 |
| ▸ | KDM5C | P41229 | 2/20 | 0.59 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.54 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.51 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.50 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | KDM5A | P29375 | 7/20 | 0.49 |
| ▸ | KDM5B | Q9UGL1 | 5/20 | 0.49 |
| ▸ | KDM4A | O75164 | 4/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KDM6B | O15054 | 1/20 | 0.46 |
| ▸ | TET3 | O43151 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1592602 | 0.88 | PRKD1 (0.61) | PIK3CAKDM4CKDM5CPRKD1PRKD2 | |
| SCHEMBL27786169 | 0.86 | PRKD1 (0.66) | PIK3CAKDM4CKDM5CPRKD1PRKD2 | |
| SCHEMBL8255945 | 0.86 | PRKD1 (0.53) | PIK3CAKDM4CKDM5CPRKD1PRKD2 | |
| SCHEMBL31143236 | 0.85 | PIK3CA (0.74) | PIK3CAKDM4CKDM5CPRKD1PRKD2 | |
| SCHEMBL1516867 | 0.85 | PIK3CA (0.74) | PIK3CAKDM4CKDM5CPRKD1PRKD2 | |
| Hydrochloric Acid SCHEMBL1252523 | 0.84 | PIK3CA (0.72) | PIK3CAKDM4CKDM5CPRKD1PRKD2 | |
| SCHEMBL1255519 | 0.84 | PIK3CA (0.72) | PIK3CAKDM4CKDM5CPRKD1PRKD2 | |
| SCHEMBL30505327 | 0.84 | PIK3CA (0.72) | PIK3CAKDM4CKDM5CPRKD1PRKD2 | |
| SCHEMBL1021177 | 0.82 | HRH3 (0.54) | PIK3CAKDM4CKDM5CPRKD1PRKD2 | |
| Hydrochloric Acid SCHEMBL23630502 | 0.81 | HRH3 (0.53) | PIK3CAKDM4CKDM5CPRKD1PRKD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY | 2023-10-19 | — | — | US | disclosed |
| CN-111511732-A | Radiolabelled compounds | 豪夫迈·罗氏有限公司 | 2020-08-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230330099-A1 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | MCL1, BCL2L1, BCL9 | PIK3CA 2377/4885KDM4C 2683/4885KDM5C 1639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.