Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 9/20 | 0.34 |
| ▸ | MMP1 | P03956 | 4/20 | 0.34 |
| ▸ | MMP3 | P08254 | 4/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20212169 | 0.94 | POLB (0.43) | POLBCNR2MEN1KMT2AMMP2 | |
| SCHEMBL3698937 | 0.94 | POLB (0.43) | POLBCNR2MEN1KMT2AMMP2 | |
| SCHEMBL18109669 | 0.94 | POLB (0.43) | POLBCNR2MEN1KMT2AMMP2 | |
| SCHEMBL15608798 | 0.94 | POLB (0.43) | POLBCNR2MEN1KMT2AMMP2 | |
| SCHEMBL2847080 | 0.94 | POLB (0.43) | POLBCNR2MEN1KMT2AMMP2 | |
| SCHEMBL4205630 | 0.85 | POLB (0.40) | POLBCNR2MEN1KMT2AMMP2 | |
| SCHEMBL4205633 | 0.85 | POLB (0.40) | POLBCNR2MEN1KMT2AMMP2 | |
| SCHEMBL8624830 | 0.82 | POLB (0.42) | POLBCNR2MEN1KMT2ACTSL | |
| SCHEMBL7376886 | 0.82 | POLB (0.42) | POLBCNR2MEN1KMT2ACTSL | |
| SCHEMBL7373925 | 0.82 | POLB (0.42) | POLBCNR2MEN1KMT2ACTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222648-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS | AstraZeneca AB (SE) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009067081-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ASTHMA, COPD, ALLERGIC RHINITIS, ALLERGIC CONJUNCTIVITIS, ATOPIC DERMATITIS, CANCER, HEPATITIS B, HEPATITIS C, HIV, HPV, BACTERIAL INFECTIONS AND DERMATOSIS | ASTRAZENECA AB (SE) | 2009-05-28 | — | — | WO | disclosed |