Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23029471 | 0.77 | HPGD (0.55) | HPGDGRIA3GRIA4SMN1; SMN2POLB | |
| SCHEMBL28474014 | 0.75 | ACACB (0.50) | HPGDGHSR | |
| SCHEMBL264413 | 0.74 | TDP1 (0.51) | HPGDKDM4ESMN1; SMN2POLBALDH1A1 | |
| SCHEMBL29510973 | 0.74 | TDP1 (0.51) | HPGDKDM4ESMN1; SMN2POLBALDH1A1 | |
| SCHEMBL263919 | 0.72 | SLC2A1 (0.44) | KDM4ESMN1; SMN2POLBALDH1A1MAPT | |
| SCHEMBL446292 | 0.72 | CHEK2 (0.48) | — | |
| SCHEMBL29751019 | 0.72 | CHEK2 (0.48) | — | |
| SCHEMBL16619560 | 0.72 | MGLL (0.65) | HPGDMEN1KMT2A | |
| SCHEMBL31549304 | 0.71 | KDM4E (0.42) | HPGDKDM4EGRIA3GRIA4SMN1; SMN2 | |
| SCHEMBL27676330 | 0.70 | HDAC6 (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112370452-A | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2021-02-19 | — | — | CN | disclosed |
| CN-107624111-B | Heterocyclic amides as kinase inhibitors | 葛兰素史密斯克莱知识产权发展有限公司 | 2020-11-03 | — | — | CN | disclosed |