Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzimidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.50 |
| ▸ | WNT3A | P56704 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 1/20 | 0.42 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzimidazole SCHEMBL16516333 | 0.96 | KDM4E (0.54) | KDM4ESMN1; SMN2RAB9AALDH1A1HPGD | |
| Benzimidazole SCHEMBL28098151 | 0.94 | KDM4E (0.51) | KDM4ESMN1; SMN2RAB9AALDH1A1HPGD | |
| Benzimidazole SCHEMBL8901469 | 0.92 | SMN1; SMN2 (0.57) | KDM4ESMN1; SMN2RAB9AALDH1A1HPGD | |
| Benzimidazole SCHEMBL16516335 | 0.92 | SMN1; SMN2 (0.57) | KDM4ESMN1; SMN2RAB9AALDH1A1HPGD | |
| Benzimidazole SCHEMBL4774682 | 0.90 | KDM4E (0.56) | KDM4ESMN1; SMN2RAB9AALDH1A1HPGD | |
| Benzimidazole SCHEMBL1883999 | 0.89 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2RAB9AALDH1A1HPGD | |
| Benzimidazole SCHEMBL158526 | 0.89 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2RAB9AALDH1A1HPGD | |
| Benzimidazole SCHEMBL4631509 | 0.89 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2RAB9AALDH1A1HPGD | |
| Benzimidazole SCHEMBL1347288 | 0.88 | KDM4E (0.50) | KDM4ESMN1; SMN2RAB9AALDH1A1HPGD | |
| Benzimidazole SCHEMBL28163067 | 0.88 | KDM4E (0.50) | KDM4ESMN1; SMN2RAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111714639-A | Composition comprising histamine release-promoting substance and benzimidazole derivative | 黄泳华 | 2020-09-29 | — | — | CN | disclosed |