Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Benzimidazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.53 |
| ▸ | WNT3A | P56704 | 2/20 | 0.53 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.45 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzimidazole SCHEMBL16516335 | 1.00 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL4774682 | 0.94 | KDM4E (0.56) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL28469449 | 0.92 | KDM4E (0.54) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL4631509 | 0.92 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL1883999 | 0.92 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL16516333 | 0.92 | KDM4E (0.54) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL158526 | 0.92 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL28163067 | 0.91 | KDM4E (0.50) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL1347288 | 0.91 | KDM4E (0.50) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD | |
| Benzimidazole SCHEMBL28189906 | 0.90 | RAB9A (0.53) | SMN1; SMN2RAB9AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108467579-B | Organic glass fiber composite material and preparation method thereof | 贵州安顺开发区埃维森航空科技开发有限公司 | 2020-05-22 | — | — | CN | claimed |
| CN-108467579-A | A kind of organic glass fiber composite material and preparation method thereof | 山东冬瑞高新技术开发有限公司 | 2018-08-31 | — | — | CN | claimed |
| US-12623250-B2 | Carbene-functionalized composite materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2026-05-12 | — | — | US | disclosed |
| US-12409473-B2 | Carbene-functionalized composite materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2025-09-09 | — | — | US | disclosed |
| US-20240351063-A1 | Carbene-Functionalized Composite Materials | THE UNIVERSITY OF WESTERN ONTARIO (CA) | 2024-10-24 | — | — | US | disclosed |
| US-20240175164-A1 | Electrochemical Deposition of N-Heterocyclic Carbenes | QUEEN’S UNIVERSITY AT KINGSTON (CA) | 2024-05-30 | — | — | US | disclosed |
| US-20240173741-A1 | Carbene-Functionalized Composite Materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2024-05-30 | — | — | US | disclosed |
| US-11801528-B2 | Carbene-functionalized composite materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2023-10-31 | — | — | US | disclosed |
| US-20220258202-A1 | Carbene-Functionalized Composite Materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2022-08-18 | — | — | US | disclosed |
| US-11383266-B2 | Carbene-functionalized composite materials | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2022-07-12 | — | — | US | disclosed |
| CN-108467579-B | Organic glass fiber composite material and preparation method thereof | 贵州安顺开发区埃维森航空科技开发有限公司 | 2020-05-22 | — | — | CN | disclosed |
| WO-2015024120-A1 | CARBENE FUNCTIONALIZED COMPOSITE MATERIALS | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 2015-02-26 | — | — | WO | disclosed |
| WO-2014011831-A1 | CARBENDAZIM-BASED CATALYTIC MATERIALS | STC.UNM (US) | 2014-01-16 | — | — | WO | disclosed |
| US-20130338092-A1 | COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2013-12-19 | — | — | US | disclosed |
| WO-2012112956-A2 | COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS | THE BROAD INSTITUTE, INC (US) | 2012-08-23 | — | — | WO | disclosed |
| WO-2012112958-A2 | HIGH-THROUGHPUT ASSAYS TO PROBE LEUKEMIA WITHIN THE STROMAL NICHE | THE BROAD INSTITUTE, INC (US) | 2012-08-23 | — | — | WO | disclosed |
| US-5663140-A | PARASITICIDES FOR HUMANS AND LIVESTOCK | BAYER AKTIENGESELLSCHAFT (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0361069-B1 | Benzimidazole-2-carboxylic-acid anilides, their use as photoprotection composition for organic materials and organic materials stabilised by these anilides | BASF AG (DE) | 1994-06-15 | — | — | EP | disclosed |
| EP-0566020-A1 | Benzimidazoles, pharmaceutical compositions thereof and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-10-20 | — | — | EP | disclosed |
| EP-0361069-A1 | Benzimidazole-2-carboxylic-acid anilides, their use as photoprotection composition for organic materials and organic materials stabilised by these anilides | BASF Aktiengesellschaft (DE) | 1990-04-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12623250-B2 | Carbene-functionalized composite materials | EPCAM, CAD, CTTN | SMN1; SMN2 407/4885RAB9A 1210/4885KDM4E 2469/4885 |
| US-20130338092-A1 | COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS | MCL1, HCLS1, RUNX1 | SMN1; SMN2 3706/4885RAB9A 2135/4885KDM4E 461/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.