Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Chloroquine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.85 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.85 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.85 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.51 |
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.85 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.85 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.85 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.85 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.85 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.85 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.85 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.85 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.85 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.85 |
| ▸ | PRNP | P04156 | 2/20 | 0.85 |
| ▸ | MTOR | P42345 | 2/20 | 0.85 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.85 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloroquine SCHEMBL28895653 | 0.95 | CHRM2 (0.90) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| Chloroquine SCHEMBL4745454 | 0.92 | CHRM2 (0.85) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| Chloroquine SCHEMBL27814047 | 0.92 | CHRM2 (0.96) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| (R)-Chloroquine SCHEMBL29429108 | 0.92 | CHRM2 (1.00) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| (R)-Chloroquine SCHEMBL134500 | 0.92 | CHRM2 (1.00) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| Chloroquine SCHEMBL29363614 | 0.92 | CHRM2 (1.00) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| Chloroquine SCHEMBL8934 | 0.92 | CHRM2 (1.00) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| Chloroquine SCHEMBL8474661 | 0.92 | CHRM2 (1.00) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| Chloroquine SCHEMBL8933 | 0.92 | CHRM2 (1.00) | CHRM2CHRM4CHRM5ADRA2ACHRM1 | |
| Chloroquine SCHEMBL23152713 | 0.91 | CHRM2 (0.98) | CHRM2CHRM4CHRM5ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-219663666-U | Esterification reactor | 山东博沂化工有限责任公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-112279762-B | Process method for synthesizing methyl ethyl oxalate by heterogeneous catalysis transesterification | 新疆至臻化工工程研究中心有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-114292182-A | Method for synthesizing efficient catalyst from alkyl oxalate | 沈阳化工大学 | 2022-04-08 | — | — | CN | disclosed |
| CN-112279762-A | Technological method for synthesizing ethyl methyl oxalate through heterogeneous catalysis ester exchange | 新疆至臻化工工程研究中心有限公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-112279763-A | Process method for synthesizing ethyl methyl oxalate by homogeneous catalysis ester exchange | 沈阳化工大学 | 2021-01-29 | — | — | CN | disclosed |
| CN-111672493-A | Alkaline mesoporous catalyst and preparation method and application thereof | 沈阳化工大学 | 2020-09-18 | — | — | CN | disclosed |