Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 0.63 |
| ▸ | HSD11B2 | P80365 | 10/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2843418 | 0.89 | HSD11B1 (0.53) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2827036 | 0.85 | HSD11B1 (0.72) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL328928 | 0.80 | HSD11B1 (0.76) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4792813 | 0.80 | HSD11B1 (0.76) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4792811 | 0.80 | HSD11B1 (0.76) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2826647 | 0.78 | HSD11B1 (0.61) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL328942 | 0.78 | HSD11B1 (0.86) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4791837 | 0.77 | HSD11B1 (1.00) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4791839 | 0.77 | HSD11B1 (1.00) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL328819 | 0.77 | HSD11B1 (1.00) | HSD11B1HSD11B2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010123838-A2 | NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |