Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28470678 | 0.97 | SMN1; SMN2 (0.37) | SMN1; SMN2KMT2ARAB9AMAPTL3MBTL1 | |
| SCHEMBL28467928 | 0.81 | — | — | |
| SCHEMBL20745088 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2ARAB9AMAPTL3MBTL1 | |
| SCHEMBL28464096 | 0.80 | — | — | |
| SCHEMBL20745446 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2KMT2ARAB9AMAPTL3MBTL1 | |
| SCHEMBL28473481 | 0.77 | — | — | |
| SCHEMBL20745437 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2KMT2ARAB9AMAPTL3MBTL1 | |
| SCHEMBL20745127 | 0.74 | SMN1; SMN2 (0.34) | SMN1; SMN2KMT2ARAB9AMAPTL3MBTL1 | |
| SCHEMBL20745907 | 0.74 | L3MBTL1 (0.36) | SMN1; SMN2KMT2ARAB9AMAPTL3MBTL1 | |
| SCHEMBL20745118 | 0.73 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2ARAB9AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111818916-A | Macrocyclic MCL-1 inhibitors and methods of use | 艾伯维公司 | 2020-10-23 | — | — | CN | disclosed |