Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2846613 | 0.97 | APP (0.45) | APPCYP2C9KCNH2PTGS1PTGS2 | |
| SCHEMBL2852606 | 0.85 | APP (0.46) | APPCYP2C9KCNH2PTGS1PTGS2 | |
| SCHEMBL2850155 | 0.83 | PSEN1 (0.50) | CYP2C9KCNH2PTGS1PTGS2PSEN1 | |
| SCHEMBL2850158 | 0.83 | PSEN1 (0.50) | CYP2C9KCNH2PTGS1PTGS2PSEN1 | |
| SCHEMBL2848843 | 0.82 | KCNH2 (0.59) | APPKCNH2PTGS1PTGS2PSEN1 | |
| SCHEMBL2848283 | 0.81 | KCNH2 (0.47) | APPKCNH2PTGS1PTGS2PSEN1 | |
| SCHEMBL2849040 | 0.75 | PSEN1 (0.48) | CYP2C9KCNH2PTGS1PTGS2PSEN1 | |
| SCHEMBL2846733 | 0.73 | KCNH2 (0.61) | APPCYP2C9KCNH2PTGS1PTGS2 | |
| SCHEMBL2850196 | 0.73 | KCNH2 (0.59) | APPCYP2C9KCNH2PTGS1PTGS2 | |
| SCHEMBL2846305 | 0.72 | PSEN1 (0.49) | CYP2C9KCNH2PTGS1PTGS2PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138901-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS, DERIVATIVES THEREOF, AND RELATED METHODS OF USE | BIOGEN IDEC MA INC (US) | 2010-12-02 | — | — | WO | claimed |