Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.61 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.61 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.61 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.61 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.61 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | APP | P05067 | 4/20 | 0.48 |
| ▸ | CNR1 | P21554 | 6/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2849874 | 0.89 | KCNH2 (0.70) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2849438 | 0.89 | KCNH2 (0.70) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2850196 | 0.83 | KCNH2 (0.59) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2850251 | 0.82 | KCNH2 (0.57) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2852746 | 0.80 | KCNH2 (0.67) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2846209 | 0.80 | APP (0.55) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2850142 | 0.80 | KCNH2 (0.72) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2846683 | 0.79 | KCNH2 (0.56) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2847065 | 0.79 | KCNH2 (0.56) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2846659 | 0.78 | APP (0.52) | KCNH2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138901-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS, DERIVATIVES THEREOF, AND RELATED METHODS OF USE | BIOGEN IDEC MA INC (US) | 2010-12-02 | — | — | WO | claimed |