Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.71 |
| ▸ | JAK2 | O60674 | 19/20 | 0.71 |
| ▸ | JAK1 | P23458 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28475374 | 1.00 | NTRK1 (0.71) | NTRK1JAK2JAK1 | |
| SCHEMBL21510310 | 0.89 | NTRK1 (0.71) | NTRK1JAK2JAK1 | |
| SCHEMBL30823617 | 0.89 | NTRK1 (0.71) | NTRK1JAK2JAK1 | |
| SCHEMBL932499 | 0.86 | NTRK1 (0.84) | NTRK1JAK2JAK1 | |
| SCHEMBL7705201 | 0.86 | NTRK1 (0.73) | NTRK1JAK2JAK1 | |
| SCHEMBL932720 | 0.86 | NTRK1 (0.84) | NTRK1JAK2JAK1 | |
| SCHEMBL28475143 | 0.85 | NTRK1 (0.62) | NTRK1JAK2 | |
| SCHEMBL28475144 | 0.85 | NTRK1 (0.62) | NTRK1JAK2 | |
| SCHEMBL2694695 | 0.85 | NTRK1 (0.81) | NTRK1JAK2JAK1 | |
| SCHEMBL2694687 | 0.85 | NTRK1 (0.81) | NTRK1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111875620-B | Pyrazolopyrimidine macrocyclic derivative and application thereof | 上海美迪西生物医药股份有限公司 | 2020-12-11 | — | — | CN | disclosed |
| CN-111875620-A | Pyrazolopyrimidine macrocyclic derivative and application thereof | 上海美迪西生物医药股份有限公司 | 2020-11-03 | — | — | CN | disclosed |