Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 20/20 | 0.84 |
| ▸ | JAK2 | O60674 | 19/20 | 0.84 |
| ▸ | JAK1 | P23458 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932499 | 1.00 | NTRK1 (0.84) | NTRK1JAK2JAK1 | |
| SCHEMBL2694695 | 0.93 | NTRK1 (0.81) | NTRK1JAK2JAK1 | |
| SCHEMBL2694687 | 0.93 | NTRK1 (0.81) | NTRK1JAK2JAK1 | |
| SCHEMBL2697125 | 0.91 | NTRK1 (1.00) | NTRK1JAK2JAK1 | |
| SCHEMBL19547427 | 0.91 | NTRK1 (1.00) | NTRK1JAK2JAK1 | |
| SCHEMBL2697130 | 0.91 | NTRK1 (1.00) | NTRK1JAK2JAK1 | |
| SCHEMBL19813158 | 0.91 | NTRK1 (0.86) | NTRK1JAK2JAK1 | |
| SCHEMBL1045338 | 0.91 | NTRK1 (0.86) | NTRK1JAK2JAK1 | |
| SCHEMBL1045335 | 0.91 | NTRK1 (0.86) | NTRK1JAK2JAK1 | |
| SCHEMBL18783276 | 0.90 | NTRK1 (0.77) | NTRK1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11091486-B2 | Process for the preparation of pyrazolo[1,5-a]pyrimidines and salts thereof | ARRAY BIOPHARMA, INC (US) | 2021-08-17 | — | — | US | disclosed |
| US-20200291026-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2020-09-17 | — | — | US | disclosed |
| US-20200291026-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2020-09-17 | — | — | US | disclosed |
| US-10758542-B2 | Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2020-09-01 | — | — | US | disclosed |
| US-10758542-B2 | Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2020-09-01 | — | — | US | disclosed |
| US-20200216451-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | ARRAY BIOPHARMA, INC. | 2020-07-09 | — | — | US | disclosed |
| US-10647730-B2 | Macrocyclic compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-10647730-B2 | Macrocyclic compounds as TRK kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2020-05-12 | — | — | US | disclosed |
| US-20190247398-A1 | FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR | LOXO ONCOLOGY, INC. | 2019-08-15 | — | — | US | disclosed |
| EP-3521291-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2019-08-07 | — | — | EP | disclosed |
| US-20130203776-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2013-08-08 | — | — | US | disclosed |
| US-20130203776-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2013-08-08 | — | — | US | disclosed |
| US-20130203776-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2013-08-08 | — | — | US | disclosed |
| EP-2571883-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| EP-2451812-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2012-05-16 | — | — | EP | disclosed |
| US-20120108568-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-20120108568-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2012-05-03 | — | — | US | disclosed |
| WO-2011146336-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-11-24 | — | — | WO | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |
| WO-2011006074-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203776-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K3 | NTRK1 31/4885JAK2 127/4885JAK1 460/4885 |
| US-20200291026-A1 | MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K3 | NTRK1 31/4885JAK2 127/4885JAK1 460/4885 |
| US-20190247398-A1 | FORMULATIONS OF A MACROCYCLIC TRK KINASE INHIBITOR | DMPK, TTK, GAK | NTRK1 28/4885JAK2 365/4885JAK1 532/4885 |
| US-11091486-B2 | Process for the preparation of pyrazolo[1,5-a]pyrimidines and salts thereof | DPYD, TYMP, UMPS | NTRK1 4624/4885JAK2 451/4885JAK1 121/4885 |
| US-20120108568-A1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | FRK, TXK, TNNI3K | NTRK1 8/4885JAK2 143/4885JAK1 137/4885 |
| US-10647730-B2 | Macrocyclic compounds as TRK kinase inhibitors | MAP3K20, MAP3K1, MAP3K3 | NTRK1 27/4885JAK2 100/4885JAK1 417/4885 |
| US-20200216451-A1 | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF | DPYD, TYMP, UMPS | NTRK1 4624/4885JAK2 451/4885JAK1 121/4885 |
| US-10758542-B2 | Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors | LTK, TXK, FRK | NTRK1 7/4885JAK2 133/4885JAK1 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.