SCHEMBL28477494

SCHEMBL28477494

C=C[C@]1(C)C[C@@H](n2ccc3c(C)ncnc32)[C@@H]2OC(C)(C)O[C@@H]21

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 20/20 0.40
WDR77 Q9BQA1 19/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22495027 1.00 PRMT5 (0.40) PRMT5WDR77
SCHEMBL22494872 1.00 PRMT5 (0.40) PRMT5WDR77
SCHEMBL23535972 0.89 PRMT5 (0.36) PRMT5WDR77
SCHEMBL22494884 0.89 PRMT5 (0.46) PRMT5WDR77
SCHEMBL28476776 0.89 PRMT5 (0.35) PRMT5WDR77
SCHEMBL22494864 0.89 PRMT5 (0.35) PRMT5WDR77
SCHEMBL22494921 0.89 PRMT5 (0.46) PRMT5WDR77
SCHEMBL30002812 0.89 PRMT5 (0.46) PRMT5WDR77
SCHEMBL28474368 0.82 PRMT5 (0.38) PRMT5WDR77
SCHEMBL19667207 0.80 PRMT5 (0.38) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111712498-A Substituted bicyclic heterocyclic compounds as PRMT5 inhibitors 鲁平有限公司 2020-09-25 CN disclosed