Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Pyridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.82 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.82 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL10552175 | 0.95 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL2323896 | 0.95 | — | — | |
| Pyridine SCHEMBL29517174 | 0.95 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL10752757 | 0.95 | — | — | |
| Pyridine SCHEMBL69088 | 0.95 | — | — | |
| Pyridine SCHEMBL563923 | 0.95 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL2323893 | 0.95 | TSHR (0.90) | TSHRNAPRTTDP1NOTUMSLC6A2 | |
| Pyridine SCHEMBL2149172 | 0.95 | — | — | |
| Pyridine SCHEMBL7997339 | 0.91 | — | — | |
| Pyridine SCHEMBL10708357 | 0.91 | TSHR (0.82) | TSHRNAPRTTDP1NOTUMSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109612610-B | Hydrogel-based color-changeable electronic skin and preparation method thereof | 重庆大学 | 2020-11-03 | — | — | CN | claimed |
| CN-109612610-B | Hydrogel-based color-changeable electronic skin and preparation method thereof | 重庆大学 | 2020-11-03 | — | — | CN | disclosed |