Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KAT5 | Q92993 | 2/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7464133 | 0.88 | GPR119 (0.45) | NR1H2KAT5KAT6AKAT8GPR119 | |
| SCHEMBL7442420 | 0.85 | GPR119 (0.49) | USP2SMN1; SMN2GPR119HPGDSTS | |
| SCHEMBL21805919 | 0.84 | NR1H2 (0.54) | NR1H2NAMPTUSP2SMN1; SMN2KAT5 | |
| SCHEMBL28062963 | 0.84 | NR1H2 (0.54) | NR1H2NAMPTUSP2SMN1; SMN2KAT5 | |
| SCHEMBL10293026 | 0.83 | NR1H2 (0.60) | NR1H2NAMPTUSP2SMN1; SMN2DDB1 | |
| SCHEMBL23579323 | 0.83 | NR1H2 (0.53) | NR1H2NAMPTUSP2SMN1; SMN2KAT5 | |
| SCHEMBL24392677 | 0.82 | NR1H2 (0.47) | NR1H2NAMPTUSP2SMN1; SMN2GPR119 | |
| SCHEMBL21063626 | 0.82 | NR1H2 (0.58) | NR1H2NAMPTUSP2SMN1; SMN2DDB1 | |
| SCHEMBL24969818 | 0.81 | NR1H2 (0.51) | NR1H2NAMPTUSP2SMN1; SMN2KAT5 | |
| SCHEMBL23578909 | 0.80 | NR1H2 (0.50) | NR1H2NAMPTUSP2SMN1; SMN2KAT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111944012-A | Aromatic amine AR and BET targeted protein degradation chimeric compound and application thereof | 成都海创药业有限公司 | 2020-11-17 | — | — | CN | disclosed |