Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.38 |
| ▸ | TET3 | O43151 | 2/20 | 0.38 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 2/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.32 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL3809544 | 0.94 | SMN1; SMN2 (0.60) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| Malic Acid SCHEMBL15877626 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| Malic Acid SCHEMBL28317492 | 0.80 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| Malic Acid SCHEMBL27748793 | 0.80 | SMN1; SMN2 (0.83) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| Malic Acid SCHEMBL9617104 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2TET2TET3TET1CA1 | |
| Malic Acid SCHEMBL367943 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| SCHEMBL8003148 | 0.80 | SMN1; SMN2 (0.40) | SMN1; SMN2CA1CA2CA7SLC22A6 | |
| Bicarbonate SCHEMBL10456880 | 0.78 | CA1 (0.37) | SMN1; SMN2CA1CA2CA7TDP1 | |
| SCHEMBL18604307 | 0.77 | CA1 (0.52) | SMN1; SMN2TET2TET3TET1OR51E2 | |
| Malic Acid SCHEMBL10337063 | 0.76 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2TET3TET1OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111732685-B | Water-absorbent resin composition, water-absorbent resin and process for producing the same | 台湾塑胶工业股份有限公司 | 2022-02-15 | — | — | CN | disclosed |
| CN-111732685-A | Water-absorbent resin composition, water-absorbent resin and process for producing the same | 台湾塑胶工业股份有限公司 | 2020-10-02 | — | — | CN | disclosed |