Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.39 |
| ▸ | TET3 | O43151 | 2/20 | 0.39 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL741143 | 0.86 | SMN1; SMN2 (0.38) | SMN1; SMN2SLC22A6CASP1 | |
| Malic Acid SCHEMBL3809544 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2TET2TET3TET1KDM4A | |
| Malic Acid SCHEMBL28486197 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2TET2TET3TET1KDM4A | |
| Malic Acid SCHEMBL3809552 | 0.79 | SMN1; SMN2 (0.62) | SMN1; SMN2TET2TET3TET1KDM4A | |
| Malic Acid SCHEMBL15877626 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2TET2TET3TET1KDM4A | |
| Malic Acid SCHEMBL2596196 | 0.78 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2TET3TET1KDM4A | |
| Bicarbonate SCHEMBL4344138 | 0.77 | CYP3A4 (0.35) | SMN1; SMN2TDP1 | |
| Malic Acid SCHEMBL15877551 | 0.76 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1KDM4A | |
| Malic Acid SCHEMBL2370349 | 0.76 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1KDM4A | |
| Malic Acid SCHEMBL28203302 | 0.76 | SMN1; SMN2 (0.65) | SMN1; SMN2TET2TET3TET1KDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 281 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11980189-B2 | Agricultural formulations, uses thereof and processes for preparation thereof | VALENT U.S.A., LLC (US) | 2024-05-14 | — | — | US | claimed |
| US-11864556-B2 | Agricultural formulations, uses thereof and processes for preparation thereof | VALENT U.S.A., LLC (US) | 2024-01-09 | — | — | US | claimed |
| US-20220079154-A1 | AGRICULTURAL FORMULATIONS, USES THEREOF AND PROCESSES FOR PREPARATION THEREOF | VALENT U.S.A. LLC | 2022-03-17 | — | — | US | claimed |
| CN-113905769-A | Superporous hydrogels, methods of manufacture thereof and articles comprising the same | 康沃特克科技公司 | 2022-01-07 | — | — | CN | claimed |
| US-11064695-B2 | Agricultural formulations, uses thereof and processes for preparation thereof | VALENT U.S.A., LLC (US) | 2021-07-20 | — | — | US | claimed |
| US-20210000114-A1 | AGRICULTURAL FORMULATIONS, USES THEREOF AND PROCESSES FOR PREPARATION THEREOF | VALENT U.S.A. LLC | 2021-01-07 | — | — | US | claimed |
| US-20190274301-A1 | AGRICULTURAL FORMULATIONS, USES THEREOF AND PROCESSES FOR PREPARATION THEREOF | VALENT U.S.A. LLC | 2019-09-12 | — | — | US | claimed |
| WO-2019161161-A1 | AGRICULTURAL FORMULATIONS, USES THEREOF AND PROCESSES FOR PREPARATION THEREOF | VALENT U.S.A. LLC (US) | 2019-08-22 | — | — | WO | claimed |
| CN-108697593-A | Have sticking peroxide compositions | 自然基因有限公司 | 2018-10-23 | — | — | CN | claimed |
| EP-3023089-A1 | STABLE AQUEOUS SUSPENSION CONCENTRATE FOR DELIVERY OF UV-LABILE WATER-INSOLUBLE BIOCIDES | ISP INVESTMENTS INC. (US) | 2016-05-25 | — | — | EP | claimed |
| WO-1997042929-A1 | COSMETIC COMPOSITION FOR REJUVENATION OF SKIN WITHOUT SKIN IRRITATION | ISP INVESTMENTS INC. (US) | 1997-11-20 | — | — | WO | claimed |
| WO-1997035555-A1 | NEW PARTIAL DENTURE CLEANSER WITH FLUORIDE | THE BLOCK DRUG COMPANY (US) | 1997-10-02 | — | — | WO | claimed |
| CN-1131675-A | Grosslinked acidic polysaccharides and their uses | HERCULES INC (US) | 1996-09-25 | — | — | CN | claimed |
| EP-0721300-A1 | SUBSTANTIVE ANTIMICROBIAL PHOSPHATES | THE PROCTER & GAMBLE COMPANY (US) | 1996-07-17 | — | — | EP | claimed |
| EP-0719129-A1 | PYROPHOSPHATE DIESTERS FOR TARTAR CONTROL | THE PROCTER & GAMBLE COMPANY (US) | 1996-07-03 | — | — | EP | claimed |
| EP-0718312-A2 | Crosslinked acidic polysaccharides and their uses | HERCULES INCORPORATED (US) | 1996-06-26 | — | — | EP | claimed |
| WO-1995008920-A1 | SUBSTANTIVE ANTIMICROBIAL PHOSPHATES | THE PROCTER & GAMBLE COMPANY (US) | 1995-04-06 | — | — | WO | claimed |
| WO-1995007684-A1 | PYROPHOSPHATE DIESTERS FOR TARTAR CONTROL | THE PROCTER & GAMBLE COMPANY (US) | 1995-03-23 | — | — | WO | claimed |
| EP-0473585-A4 | ADHESIVE COMPOSITION | — | 1993-02-17 | — | — | EP | claimed |
| US-4910247-A | Salt of alkyl vinyl ether-maleic acid copolymer | GAF CHEMICALS CORPORATION (US) | 1990-03-20 | — | — | US | claimed |