Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.48 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSSK1B | Q9BXA7 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29411959 | 1.00 | PARP1 (0.48) | PARP1PKN1PKN2JAK2JAK1 | |
| SCHEMBL28903059 | 0.90 | HDAC1 (0.47) | PARP1PKN1PKN2JAK2JAK1 | |
| SCHEMBL29411976 | 0.90 | HDAC1 (0.47) | PARP1PKN1PKN2JAK2JAK1 | |
| SCHEMBL28484147 | 0.87 | PARP1 (0.51) | PARP1PKN1PKN2MEN1KMT2A | |
| SCHEMBL29411964 | 0.87 | PARP1 (0.51) | PARP1PKN1PKN2MEN1KMT2A | |
| SCHEMBL28484710 | 0.85 | HDAC1 (0.48) | PARP1PKN1PKN2JAK2JAK1 | |
| SCHEMBL29411910 | 0.85 | HDAC1 (0.48) | PARP1PKN1PKN2JAK2JAK1 | |
| SCHEMBL28484826 | 0.84 | PKN1 (0.48) | PARP1PKN1PKN2JAK2JAK1 | |
| SCHEMBL29412003 | 0.84 | PKN1 (0.48) | PARP1PKN1PKN2JAK2JAK1 | |
| SCHEMBL29412030 | 0.82 | CASR (0.47) | PARP1PKN1PKN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978301-A | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2020-11-24 | — | — | CN | disclosed |