Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22873430 | 0.83 | CRBN (0.48) | CRBNESR1ALDH1A1LMNAHTT | |
| SCHEMBL25036258 | 0.78 | CRBN (0.48) | CRBNESR1ALDH1A1LMNAHTT | |
| SCHEMBL20046266 | 0.78 | CRBN (0.74) | CRBNALDH1A1DDB1ARIKZF3 | |
| SCHEMBL29426684 | 0.78 | CRBN (0.74) | CRBNALDH1A1DDB1ARIKZF3 | |
| SCHEMBL31382037 | 0.76 | CRBN (0.39) | CRBNALDH1A1LMNAHTTDDB1 | |
| SCHEMBL26641286 | 0.76 | CRBN (0.39) | CRBNALDH1A1LMNAHTTDDB1 | |
| SCHEMBL26641517 | 0.76 | ALDH1A1 (0.43) | CRBNALDH1A1LMNAHTTDDB1 | |
| SCHEMBL30643709 | 0.76 | ALDH1A1 (0.43) | CRBNALDH1A1LMNAHTTDDB1 | |
| SCHEMBL25367969 | 0.76 | CRBN (0.39) | CRBNALDH1A1LMNAHTTDDB1 | |
| SCHEMBL22581117 | 0.75 | CRBN (0.58) | CRBNESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111825657-A | Dual-function chimeric heterocyclic compound for targeted degradation of androgen receptor and application thereof | 成都海创药业有限公司 | 2020-10-27 | — | — | CN | disclosed |