Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PDE6D | O43924 | 1/20 | 0.50 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.50 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29411917 | 1.00 | HRH1 (0.56) | HRH1KCNH2CYP2D6TNFMEN1 | |
| SCHEMBL28490101 | 0.90 | KCNH2 (0.50) | HRH1KCNH2CYP2D6MEN1KMT2A | |
| SCHEMBL29411904 | 0.90 | KCNH2 (0.50) | HRH1KCNH2CYP2D6MEN1KMT2A | |
| SCHEMBL28555682 | 0.84 | CFTR (0.53) | CYP2D6TNFMEN1ALDH1A1KMT2A | |
| SCHEMBL9736479 | 0.77 | ALDH1A1 (0.40) | HRH1KCNH2CYP2D6MEN1ALDH1A1 | |
| SCHEMBL28901296 | 0.76 | TAAR1 (0.65) | HRH1KCNH2CYP2D6TNFMEN1 | |
| SCHEMBL28901292 | 0.76 | TAAR1 (0.65) | HRH1KCNH2CYP2D6TNFMEN1 | |
| SCHEMBL29597271 | 0.76 | TAAR1 (0.65) | HRH1KCNH2CYP2D6TNFMEN1 | |
| SCHEMBL28557880 | 0.73 | ALDH1A1 (0.52) | KCNH2CYP2D6MEN1ALDH1A1KMT2A | |
| SCHEMBL152719 | 0.71 | TNF (0.65) | CYP2D6TNFMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978301-B | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2022-08-02 | — | — | CN | disclosed |
| CN-111978301-A | Benzimidazole compound with endothelial lipase inhibition effect and application thereof | 盐城师范学院 | 2020-11-24 | — | — | CN | disclosed |