Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 20/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | DAPK1 | P53355 | 3/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.53 |
| ▸ | BMP2K | Q9NSY1 | 3/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.53 |
| ▸ | MYLK2 | Q9H1R3 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.53 |
| ▸ | CIT | O14578 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.53 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.53 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.53 |
| ▸ | TLK1 | Q9UKI8 | 1/20 | 0.53 |
| ▸ | GAK | O14976 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28480056 | 0.91 | AAK1 (0.58) | AAK1CYP3A4DAPK1MKNK2BMP2K | |
| SCHEMBL28480497 | 0.90 | AAK1 (0.62) | AAK1CYP3A4DAPK1MKNK2BMP2K | |
| SCHEMBL28478444 | 0.88 | AAK1 (0.60) | AAK1CYP3A4MKNK2 | |
| SCHEMBL28484965 | 0.88 | AAK1 (0.61) | AAK1CYP3A4 | |
| SCHEMBL28481850 | 0.87 | AAK1 (0.49) | AAK1CYP3A4DAPK1MKNK2BMP2K | |
| SCHEMBL28487434 | 0.82 | AAK1 (0.55) | AAK1CYP3A4DAPK1MKNK2BMP2K | |
| SCHEMBL20574510 | 0.82 | AAK1 (0.59) | AAK1CYP3A4DAPK1MKNK2BMP2K | |
| SCHEMBL20574513 | 0.82 | AAK1 (0.59) | AAK1CYP3A4DAPK1MKNK2BMP2K | |
| SCHEMBL28480653 | 0.82 | AAK1 (0.56) | AAK1CYP3A4DAPK1MKNK2BMP2K | |
| SCHEMBL28482009 | 0.81 | AAK1 (0.67) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112142655-A | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-12-29 | — | — | CN | disclosed |
| CN-108368084-B | Biaryl kinase inhibitors | 百时美施贵宝公司 | 2020-10-16 | — | — | CN | disclosed |