Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28494628 | 0.82 | PTGER4 (0.37) | HDAC1HDAC8HDAC6PTGER4PTGDR | |
| SCHEMBL10085682 | 0.81 | HDAC3 (0.44) | HDAC11HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL28486517 | 0.81 | BCHE (0.43) | HDAC11HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL28487995 | 0.81 | EGLN2 (0.39) | HDAC11HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL28487314 | 0.80 | PTGER4 (0.35) | HDAC1HDAC4HDAC6PTGER4PTGDR | |
| SCHEMBL12583772 | 0.79 | CYSLTR1 (0.47) | HDAC11HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL28493538 | 0.78 | CBLB (0.34) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL28493532 | 0.78 | PTGER4 (0.48) | HDAC1HDAC3HDAC2HDAC10HDAC8 | |
| SCHEMBL28480177 | 0.78 | KCNH2 (0.36) | HDAC6PTGER4PTGDRTBXA2RPTGER1 | |
| SCHEMBL28484362 | 0.76 | NPC1 (0.38) | PTGER4PTGDRTBXA2RPTGER1PTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111989311-B | Compound for inhibiting PGE2/EP4 signal transduction, preparation method thereof and application thereof in medicines | 凯复(苏州)生物医药有限公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-111989311-A | Compound for inhibiting PGE2/EP4 signal transduction, preparation method thereof and application thereof in medicines | 凯复(苏州)生物医药有限公司 | 2020-11-24 | — | — | CN | disclosed |