Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CRHBP | P24387 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28919873 | 0.88 | KMT2A (0.54) | KMT2AALDH1A1MAPTCRHBPHTT | |
| SCHEMBL28489842 | 0.85 | KMT2A (0.57) | KMT2AALDH1A1MAPTATMCYP1A2 | |
| SCHEMBL19512129 | 0.80 | KMT2A (0.45) | KMT2AALDH1A1MAPTCYP1A2CYP2C19 | |
| SCHEMBL27988230 | 0.80 | MAPT (0.49) | KMT2AALDH1A1MAPTTSHRLMNA | |
| SCHEMBL15247099 | 0.80 | KMT2A (0.55) | KMT2AALDH1A1MAPTCRHBPHTT | |
| SCHEMBL28386352 | 0.80 | KMT2A (0.65) | KMT2AALDH1A1MAPTCRHBPHTT | |
| Phosphine SCHEMBL22345943 | 0.79 | MAPT (0.48) | KMT2AALDH1A1MAPTTSHRLMNA | |
| SCHEMBL10001382 | 0.79 | KMT2A (0.60) | KMT2AALDH1A1MAPTCRHBPHTT | |
| SCHEMBL29936263 | 0.79 | KMT2A (0.60) | KMT2AALDH1A1MAPTCRHBPHTT | |
| SCHEMBL28906813 | 0.78 | KMT2A (0.63) | KMT2AALDH1A1MAPTCYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279808-A | Cystic fibrosis transmembrane transduction modulator modulators | 弗特克斯药品有限公司 | 2021-01-29 | — | — | CN | disclosed |
| CN-112250627-A | Cystic fibrosis transmembrane transduction modulator modulators | 弗特克斯药品有限公司 | 2021-01-22 | — | — | CN | disclosed |
| CN-107690281-B | Cystic fibrosis transmembrane transduction modulator modulators | 弗特克斯药品有限公司 | 2020-11-17 | — | — | CN | disclosed |