SCHEMBL10001382

SCHEMBL10001382

O=C(Oc1c(F)c(F)cc(F)c1F)c1cccnc1

nearest known ligand 0.60

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 9/20 0.60
▸ ATM Q13315 1/20 0.60
▸ ALDH1A1 P00352 5/20 0.57
▸ MAPT P10636 3/20 0.53
▸ CRHBP P24387 1/20 0.53
▸ HTT P42858 1/20 0.53
▸ CRHR2 Q13324 1/20 0.53
▸ CYP1A2 P05177 3/20 0.52
▸ CYP2C19 P33261 3/20 0.52
▸ CYP2C9 P11712 2/20 0.52
▸ TSHR P16473 2/20 0.52
▸ LMNA P02545 2/20 0.52
▸ THRB P10828 1/20 0.52
▸ KDM4E B2RXH2 1/20 0.50
▸ CYP3A4 P08684 1/20 0.50
▸ HSD17B10 Q99714 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29936263 1.00 KMT2A (0.60) KMT2AATMALDH1A1MAPTCRHBP
SCHEMBL15247099 0.92 KMT2A (0.55) KMT2AATMALDH1A1MAPTCRHBP
SCHEMBL28386352 0.89 KMT2A (0.65) KMT2AATMALDH1A1MAPTCRHBP
SCHEMBL31591144 0.80 TSHR (0.48) KMT2AALDH1A1MAPTTSHRLMNA
SCHEMBL25308546 0.79 KMT2A (0.57) KMT2AATMALDH1A1MAPTCYP1A2
SCHEMBL6726742 0.79 KMT2A (0.50) KMT2AATMMAPTKDM4E
SCHEMBL28489841 0.79 KMT2A (0.64) KMT2AATMALDH1A1MAPTCRHBP
SCHEMBL6726735 0.77 KCNQ3 (0.41) KMT2AATMALDH1A1MAPTKDM4E
SCHEMBL416586 0.77 KCNQ3 (0.41) KMT2AATMALDH1A1MAPTKDM4E
SCHEMBL29525674 0.77 KCNQ3 (0.41) KMT2AATMALDH1A1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022117714-A1 IMAGING METHODS AND RADIOTRACERS FOR USE THEREIN VESTLANDETS INNOVASJONS SELSKAP AS (VIS) (NO) 2022-06-09 — — WO disclosed
EP-3353152-B1 METHOD NORSK MEDISINSK SYKLOTRONSENTER AS (NO) 2021-09-15 — — EP disclosed
US-10869942-B2 Method NORSK MEDISINSK SYKLOTRONSENTER AS (NO) 2020-12-22 — — US disclosed
US-8530620-B2 Radiolabelling reagents and methods GE HEALTHCARE LIMITED (GB) 2013-09-10 — — US disclosed
US-20120022227-A1 RADIOLABELLING REAGENTS AND METHODS GE HEALTHCARE LIMITED (GB) 2012-01-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10869942-B2 Method MPI, DUT, NT5E KMT2A 3393/4885ATM 4369/4885ALDH1A1 1340/4885
US-20120022227-A1 RADIOLABELLING REAGENTS AND METHODS ANPEP, DNPEP, QRFPR KMT2A 3853/4885ATM 4038/4885ALDH1A1 2635/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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