Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | MYC | P01106 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2034454 | 0.84 | KDM4E (0.72) | LCKFYNKDM4EPOLBPKM | |
| SCHEMBL25165612 | 0.82 | LCK (0.53) | LCKFYNKDM4EPOLBPKM | |
| SCHEMBL17494276 | 0.82 | HSD17B10 (0.46) | LCKFYNKDM4EPOLBPKM | |
| SCHEMBL28270343 | 0.81 | KDM4E (0.54) | LCKFYNKDM4EPOLBPKM | |
| SCHEMBL18669122 | 0.81 | KDM4E (0.54) | LCKFYNKDM4EPOLBPKM | |
| SCHEMBL505418 | 0.81 | LCK (0.56) | LCKFYNKDM4EPKMALDH1A1 | |
| SCHEMBL31216003 | 0.79 | LCK (0.53) | LCKFYNKDM4EPOLBPKM | |
| SCHEMBL28497490 | 0.78 | PKM (0.76) | LCKFYNKDM4EPOLBPKM | |
| SCHEMBL642897 | 0.78 | KDM4E (0.54) | LCKFYNKDM4EPOLBPKM | |
| SCHEMBL9197473 | 0.78 | LCK (0.51) | LCKFYNKDM4EPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112110918-B | Spiro substituted pyrimido cyclic compounds, process for their preparation and their use in medicine | 劲方医药科技(上海)有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-112110918-A | Spiro-substituted pyrimido-cyclic compounds, preparation method and medical application thereof | 劲方医药科技(上海)有限公司 | 2020-12-22 | — | — | CN | disclosed |