Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 13/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4351623 | 0.93 | MPO (0.54) | MPOSLC6A4HTR1A | |
| SCHEMBL16433177 | 0.92 | MPO (0.55) | MPOSLC6A4HTR1A | |
| SCHEMBL9213281 | 0.84 | HTR2A (0.48) | MPOSLC6A4HTR2AHTR1A | |
| SCHEMBL11558417 | 0.83 | NQO2 (0.53) | SLC6A4HTR2AKMT2AMEN1MAPT | |
| SCHEMBL25307628 | 0.83 | MPO (0.60) | MPOSLC6A4HTR2ATRPM8KMT2A | |
| SCHEMBL9215791 | 0.80 | SLC6A4 (0.52) | SLC6A4HTR2ATRPM8KMT2AHTR1A | |
| SCHEMBL14785222 | 0.79 | HTR2A (0.46) | HTR2A | |
| SCHEMBL16433094 | 0.79 | MAPT (0.57) | SLC6A4HTR2ATRPM8KMT2AHTR1A | |
| SCHEMBL16432776 | 0.79 | SLC6A4 (0.51) | SLC6A4HTR2ATRPM8KMT2AHTR1A | |
| SCHEMBL16433285 | 0.78 | MAPT (0.56) | SLC6A4HTR2ATRPM8KMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112209917-B | Application of heterocyclic substituted phenylpiperazine or phenylpiperidine derivatives in antidepressant drugs | 上海医药工业研究院 | 2021-09-24 | — | — | CN | disclosed |
| CN-112209917-A | Application of heterocyclic substituted phenyl piperazine (pyridine) derivatives in antidepressant drugs | 上海医药工业研究院 | 2021-01-12 | — | — | CN | disclosed |