Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212760 | 0.83 | ACACB (0.50) | ACACBLMNAALDH1A1GAAKMT2A | |
| SCHEMBL3805723 | 0.80 | MAPK14 (0.45) | ACACBLMNAALDH1A1GAAKMT2A | |
| SCHEMBL2964048 | 0.80 | KDM4E (0.42) | ACACBLMNAALDH1A1GAAKMT2A | |
| SCHEMBL5211607 | 0.76 | ACACB (0.42) | ACACBLMNAALDH1A1GAAKMT2A | |
| SCHEMBL3905049 | 0.72 | MAPK14 (0.40) | ACACBLMNAALDH1A1GAAKMT2A | |
| SCHEMBL5432856 | 0.72 | ACACB (0.48) | ACACBLMNAALDH1A1GAAKMT2A | |
| SCHEMBL29987888 | 0.72 | — | — | |
| SCHEMBL148439 | 0.72 | — | — | |
| SCHEMBL1644275 | 0.71 | MAPK14 (0.42) | ACACBLMNAALDH1A1GAAKMT2A | |
| SCHEMBL3110744 | 0.71 | ACACB (0.53) | ACACBLMNAALDH1A1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279888-A | Polypeptide inhibitor of APC/Asef interaction and application thereof | 上海交通大学医学院 | 2021-01-29 | — | — | CN | claimed |
| CN-112209991-A | Tripeptide inhibitor of APC/Asef interaction and application thereof | 上海交通大学医学院 | 2021-01-12 | — | — | CN | claimed |
| CN-112279888-B | Polypeptide inhibitor of APC/Asef interaction and application thereof | 上海交通大学医学院 | 2022-09-13 | — | — | CN | disclosed |
| CN-112209991-B | Tripeptide inhibitor of APC/Asef interaction and application thereof | 上海交通大学医学院 | 2022-08-12 | — | — | CN | disclosed |
| CN-112279888-A | Polypeptide inhibitor of APC/Asef interaction and application thereof | 上海交通大学医学院 | 2021-01-29 | — | — | CN | disclosed |
| CN-112209991-A | Tripeptide inhibitor of APC/Asef interaction and application thereof | 上海交通大学医学院 | 2021-01-12 | — | — | CN | disclosed |