Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 6/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5212760 | 0.85 | ACACB (0.50) | ACACBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL5799133 | 0.82 | ACACB (0.51) | ACACBALDH1A1SMN1; SMN2MAPTGRM5 | |
| SCHEMBL5211777 | 0.82 | ACACB (0.46) | ACACBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL10020219 | 0.79 | GRM5 (0.53) | ALDH1A1SMN1; SMN2LMNAGRM5GRM4 | |
| SCHEMBL708798 | 0.76 | FFAR1 (0.56) | GRM5GRM4TRPV3FFAR1 | |
| SCHEMBL5802143 | 0.76 | ACACB (0.48) | ACACB | |
| SCHEMBL5211607 | 0.73 | ACACB (0.42) | ACACBALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL709297 | 0.72 | GRM5 (0.42) | ACACBGRM5MAPK14GRM4TRPV3 | |
| SCHEMBL708817 | 0.72 | ACACB (0.59) | ACACBGRM5GRM4TRPV3 | |
| SCHEMBL13989095 | 0.71 | FFAR4 (0.43) | ACACBLMNAGAAGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217600-B1 | FUNGICIDAL BICYCLIC PYRAZOLES | DU PONT (US) | 2012-12-05 | — | — | EP | disclosed |
| US-8288375-B2 | Fungicidal bicyclic pyrazoles | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2012-10-16 | — | — | US | disclosed |
| US-20100273775-A1 | FUNGICIDAL BICYCLIC PYRAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-10-28 | — | — | US | disclosed |
| EP-2217600-A2 | FUNGICIDAL BICYCLIC PYRAZOLES | E. I. du Pont de Nemours and Company (US) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009076440-A2 | FUNGICIDAL BICYCLIC PYRAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-06-18 | — | — | WO | disclosed |
| WO-2006055245-A2 | PROCESS FOR PREPARING PYRAZOLOPYRIDINE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-26 | — | — | WO | disclosed |
| US-6787555-B2 | SUCH AS 4-(4-FLUOROPHENYL)-5-(2-PHENYLMETHYLAMINO)PYRIMIDIN-4-YL)-1-ETHOXYMETHYL -(1,2,3)TRIAZOLE FOR INHIBITION OF RELEASE OF INFLAMMATORY INTERLEUKINS; FOR TREATMENT OF OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, AND CONGESTIVE HEART FAILURE | THE PROCTER & GAMBLE COMPANY | 2004-09-07 | — | — | US | disclosed |
| US-6727364-B2 | ANTIINFLAMMATORY AGENTS | THE PROCTER & GAMBLE COMPANY | 2004-04-27 | — | — | US | disclosed |
| EP-1392681-A1 | TRIAZOLE COMPOUNDS USEFUL IN TREATING DISEASES ASSOCIATED WITH UNWANTED CYTOKINE ACTIVITY | THE PROCTER & GAMBLE COMPANY (US) | 2004-03-03 | — | — | EP | disclosed |
| EP-1383759-A1 | TRIAZOLE COMPOUNDS USEFUL IN TREATING DISEASES ASSOCIATED WITH UNWANTED CYTOKINE ACTIVITY | The Procter & Gamble Company (US) | 2004-01-28 | — | — | EP | disclosed |
| US-20030100558-A1 | Triazole compounds useful in treating diseases associated with unwanted cytokine activity | PROCTER & GAMBLE COMPANY, THE | 2003-05-29 | — | — | US | disclosed |
| US-20030013712-A1 | Triazole compounds useful in treating diseases associated with unwanted cytokine activity | PROCTER & GAMBLE COMPANY, THE | 2003-01-16 | — | — | US | disclosed |
| WO-2002088108-A1 | TRIAZOLE COMPOUNDS USEFUL IN TREATING DISEASES ASSOCIATED WITH UNWANTED CYTOKINE ACTIVITY | THE PROCTER & GAMBLE COMPANY (US) | 2002-11-07 | — | — | WO | disclosed |
| WO-2002088113-A1 | TRIAZOLE COMPOUNDS USEFUL IN TREATING DISEASES ASSOCIATED WITH UNWANTED CYTOKINE ACTIVITY | THE PROCTER & GAMBLE COMPANY (US) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100558-A1 | Triazole compounds useful in treating diseases associated with unwanted cytokine activity | IL4, IL1A, IL2 | ACACB 4295/4885ALDH1A1 289/4885SMN1; SMN2 4100/4885 |
| US-20100273775-A1 | FUNGICIDAL BICYCLIC PYRAZOLES | CYP1B1, CBR1, CYP1A1 | ACACB 3331/4885ALDH1A1 458/4885SMN1; SMN2 3196/4885 |
| US-20030013712-A1 | Triazole compounds useful in treating diseases associated with unwanted cytokine activity | IL4, IL1A, IL2 | ACACB 4295/4885ALDH1A1 289/4885SMN1; SMN2 4100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.