Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 18/20 | 0.68 |
| ▸ | CCNT1 | O60563 | 17/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.68 |
| ▸ | CDK2 | P24941 | 5/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | ABL2 | P42684 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28497624 | 0.85 | CDK9 (0.73) | CDK9CCNT1CCNA2CDK2USP2 | |
| SCHEMBL30507454 | 0.85 | CDK9 (0.73) | CDK9CCNT1CCNA2CDK2USP2 | |
| SCHEMBL28503868 | 0.85 | CCNT1 (0.75) | CDK9CCNT1CCNA2CDK2 | |
| SCHEMBL30507390 | 0.81 | CCNT1 (1.00) | CDK9CCNT1CCNA2CDK2CDK1 | |
| SCHEMBL28513182 | 0.81 | CCNT1 (1.00) | CDK9CCNT1CCNA2CDK2CDK1 | |
| SCHEMBL4096927 | 0.81 | USP2 (0.67) | CDK9CCNT1CCNA2CDK2USP2 | |
| SCHEMBL19664562 | 0.80 | CDK9 (0.62) | CDK9CCNT1CCNA2CDK2USP2 | |
| SCHEMBL15486551 | 0.79 | CCNT1 (0.58) | CDK9CCNT1CCNA2CDK2USP2 | |
| SCHEMBL15486698 | 0.79 | CCNT1 (0.60) | CDK9CCNT1CCNA2CDK2LMNA | |
| SCHEMBL30507287 | 0.78 | CDK9 (0.73) | CDK9CCNT1CCNA2CDK2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112010844-A | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2020-12-01 | — | — | CN | claimed |
| CN-112010844-B | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2023-07-25 | — | — | CN | disclosed |
| CN-112010844-A | Preparation method and application of N- (pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor | 中国药科大学 | 2020-12-01 | — | — | CN | disclosed |