Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Donepezil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 8/20 | 0.96 |
| ▸ | BCHE | P06276 | 8/20 | 0.96 |
| ▸ | FAAH | O00519 | 1/20 | 0.96 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.96 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.96 |
| ▸ | PDE5A | O76074 | 1/20 | 0.96 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.96 |
| ▸ | APP | P05067 | 1/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.96 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.96 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.96 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.96 |
| ▸ | DRD4 | P21917 | 1/20 | 0.96 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.96 |
| ▸ | MAOB | P27338 | 1/20 | 0.96 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.96 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Donepezil SCHEMBL8265876 | 0.98 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL12043710 | 0.98 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL3516 | 0.98 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL3851203 | 0.98 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL2149 | 0.98 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL17352708 | 0.97 | BCHE (0.98) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL1815 | 0.97 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL4979379 | 0.97 | BCHE (0.98) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL1559622 | 0.97 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL5060933 | 0.97 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7674 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144762-A1 | TRANSDERMAL DELIVERY SYSTEM WITH A MICROPOROUS MEMBRANE HAVING SOLVENT-FILLED PORES | CORIUM, LLC (US) | 2026-05-28 | — | — | US | claimed |
| CN-122075598-A | Edible bird's nest acid preparation for preventing Alzheimer's disease | — | 2026-05-26 | — | — | CN | claimed |
| US-12616686-B2 | Donepezil oral films | XIAMEN LP PHARMACEUTICAL CO., LTD. (CN) | 2026-05-05 | — | — | US | claimed |
| US-12582637-B2 | Topical formulation for intradermal application and uses thereof | ARCTIC THERAPEUTICS HF (IS) | 2026-03-24 | — | — | US | claimed |
| EP-4673215-A1 | GBA1 AND GCS DUAL MODULATOR | ONO Pharmaceutical Co., Ltd. (JP) | 2026-01-07 | — | — | EP | claimed |
| US-20250375444-A1 | METHOD OF TREATING ALZHEIMER’S DISEASE | AMYRIAD PHARMA INC (US) | 2025-12-11 | — | — | US | claimed |
| US-20250375396-A1 | SODIUM BICARBONATE IN SITU CONVERSION DRIVEN TRANSDERMAL DELIVERY OF AMINE DRUG | CORIUM LLC (US) | 2025-12-11 | — | — | US | claimed |
| WO-2025229537-A1 | PHARMACEUTICAL COMBINATION OF DONEPEZIL AND CEVIMELINE | LUKA ASSETS INC. (US) | 2025-11-06 | — | — | WO | claimed |
| EP-4643857-A1 | PHARMACEUTICAL COMBINATION OF DONEPEZIL AND CEVIMELINE | Luka Assets Inc. (US) | 2025-11-05 | — | — | EP | claimed |
| US-20250325496-A1 | SODIUM BICARBONATE IN SITU CONVERSION DRIVEN TRANSDERMAL DELIVERY OF AMINE DRUG | CORIUM LLC (US) | 2025-10-23 | — | — | US | claimed |
| WO-2000002549-A2 | COMPOSITION FOR AND METHOD OF TREATING NEUROLOGICAL DISORDERS | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-01-20 | — | — | WO | claimed |
| EP-0970695-A1 | Methods for increasing levels of acetylcholine | ELI LILLY AND COMPANY (US) | 2000-01-12 | — | — | EP | claimed |
| EP-0966964-A1 | Methods for increasing levels of acetylcholine | ELI LILLY AND COMPANY (US) | 1999-12-29 | — | — | EP | claimed |
| WO-1999065309-A1 | METHODS FOR INCREASING LEVELS OF ACETYLCHOLINE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | claimed |
| WO-1999065489-A1 | METHODS FOR INCREASING LEVELS OF ACETYLCHOLINE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | claimed |
| US-5985864-A | USEFUL FOR THE TREATMENT OF SENILE DEMENTIA, IN PARTICULAR BEING USEFUL FOR PREVENTION, TREATMENT AND AMELIORATION OF ALZHEIMER DISEASE | EISAI CO., LTD. (JP) | 1999-11-16 | — | — | US | claimed |
| EP-0947193-A2 | Percutaneously applicable preparation and suppository containing an antidementia medicament | Eisai Co., Ltd. (JP) | 1999-10-06 | — | — | EP | claimed |
| WO-1997048391-A2 | METHODS AND COMPOSITIONS COMPRISING R-IBUPROFEN | ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE (US) | 1997-12-24 | — | — | WO | claimed |
| WO-1997046526-A1 | STABLE POLYMORPHS OF DONEPEZIL (1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON)-2-YL]METHYLPIPERIDINE) HYDROCHLORIDE AND PROCESS FOR PRODUCTION | EISAI CO., LTD. (JP) | 1997-12-11 | — | — | WO | claimed |
| WO-1997046527-A1 | POLYMORPHS OF DONEPEZIL HYDROCHLORIDE AND PROCESS FOR PRODUCTION | EISAI CO., LTD. (JP) | 1997-12-11 | — | — | WO | claimed |