Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 13/20 | 0.60 |
| ▸ | KDR | P35968 | 5/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.58 |
| ▸ | KIT | P10721 | 3/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.58 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.58 |
| ▸ | FLT1 | P17948 | 2/20 | 0.58 |
| ▸ | FLT4 | P35916 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | MET | P08581 | 2/20 | 0.58 |
| ▸ | TEK | Q02763 | 2/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | ERN1 | O75460 | 1/20 | 0.58 |
| ▸ | STK10 | O94804 | 1/20 | 0.58 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29729414 | 0.88 | RET (0.72) | RETKDRAURKBKITPDGFRA | |
| SCHEMBL28492935 | 0.88 | RET (0.60) | RETKDRAURKBKITPDGFRA | |
| SCHEMBL19957132 | 0.88 | RET (0.72) | RETKDRAURKBKITPDGFRA | |
| SCHEMBL28492198 | 0.86 | RET (0.59) | RETKDRAURKBKITPDGFRA | |
| SCHEMBL19957010 | 0.85 | RET (0.68) | RETKDRAURKBKITPDGFRA | |
| SCHEMBL28796987 | 0.84 | FGFR2 (0.53) | KDRAURKBKITPDGFRAFGFR2 | |
| SCHEMBL19956973 | 0.83 | RET (0.65) | RETKDRAURKBKITPDGFRA | |
| SCHEMBL1249791 | 0.82 | PDGFRA (0.77) | RETKDRAURKBKITPDGFRA | |
| SCHEMBL1892205 | 0.80 | KDR (0.66) | RETKDRAURKBKITPDGFRA | |
| SCHEMBL12411989 | 0.78 | KDR (0.65) | RETKDRAURKBKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111892536-B | Substituted quinoline carboxamides and their use | 北京福元医药股份有限公司 | 2022-06-28 | — | — | CN | claimed |
| CN-111892536-A | Substituted quinoline carboxamides and their use | 北京福元医药股份有限公司 | 2020-11-06 | — | — | CN | claimed |
| CN-111892536-B | Substituted quinoline carboxamides and their use | 北京福元医药股份有限公司 | 2022-06-28 | — | — | CN | disclosed |
| CN-111892536-A | Substituted quinoline carboxamides and their use | 北京福元医药股份有限公司 | 2020-11-06 | — | — | CN | disclosed |