Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 17/20 | 0.90 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.49 |
| ▸ | GPR34 | Q9UPC5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21359107 | 1.00 | YAP1 (0.90) | YAP1GPR132ITGB3ITGA2BGPR34 | |
| SCHEMBL28493245 | 0.96 | YAP1 (0.86) | YAP1GPR34 | |
| SCHEMBL21359089 | 0.96 | YAP1 (0.86) | YAP1GPR34 | |
| SCHEMBL23296225 | 0.95 | YAP1 (1.00) | YAP1ITGB3ITGA2BGPR34 | |
| SCHEMBL19974592 | 0.95 | YAP1 (1.00) | YAP1ITGB3ITGA2BGPR34 | |
| SCHEMBL19982108 | 0.95 | YAP1 (1.00) | YAP1ITGB3ITGA2BGPR34 | |
| SCHEMBL21358984 | 0.93 | YAP1 (0.81) | YAP1GPR34 | |
| SCHEMBL28490544 | 0.93 | YAP1 (0.81) | YAP1GPR34 | |
| SCHEMBL21366286 | 0.93 | YAP1 (0.91) | YAP1 | |
| SCHEMBL24043544 | 0.93 | YAP1 (0.91) | YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111989100-A | YAP1 inhibitors targeting YAP1 interaction with OCT4 | H·李·莫菲特癌症中心研究有限公司 | 2020-11-24 | — | — | CN | disclosed |