Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.61 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | IL2 | P60568 | 4/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.39 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.38 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28507208 | 0.90 | MAP4K1 (0.48) | MAP4K1BRD4IL2MAP3K11TNIK | |
| SCHEMBL28514890 | 0.85 | MAP4K1 (0.56) | MAP4K1IL2 | |
| SCHEMBL28513458 | 0.82 | MAP4K1 (0.48) | MAP4K1MAPK8MAPK9MAPK10 | |
| SCHEMBL31344455 | 0.82 | MAP4K1 (0.68) | MAP4K1IL2PIK3CGTNIK | |
| SCHEMBL28829874 | 0.81 | MAP4K1 (0.67) | MAP4K1IL2PIK3CGTNIK | |
| SCHEMBL28502462 | 0.81 | MAP4K1 (0.56) | MAP4K1IL2MAP3K11 | |
| SCHEMBL21592926 | 0.80 | MAP4K1 (0.78) | MAP4K1IL2PIK3CGMAP3K11TNIK | |
| SCHEMBL29086742 | 0.80 | MAP4K1 (0.48) | MAP4K1BRD4IL2PIK3CG | |
| SCHEMBL29888822 | 0.80 | MAP4K1 (0.48) | MAP4K1BRD4IL2PIK3CG | |
| SCHEMBL28502371 | 0.80 | MAP4K1 (0.52) | MAP4K1BRD4PIK3CGMAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |