Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28504203 | 0.89 | INSR (0.49) | PIK3CGDYRK1APIK3CAPIK3CDAXL | |
| SCHEMBL28507613 | 0.85 | DYRK1A (0.49) | MAP4K1PIK3CGDYRK1APIK3CAPIK3CD | |
| SCHEMBL28500742 | 0.84 | PIK3CD (0.49) | MAP4K1PIK3CGDYRK1APIK3CAPIK3CD | |
| SCHEMBL28509455 | 0.80 | BRD4 (0.59) | MAP4K1PIK3CGDYRK1APIK3CAPIK3CD | |
| SCHEMBL28501983 | 0.80 | MAP4K1 (0.61) | MAP4K1PIK3CGMAP3K11BRD4 | |
| SCHEMBL29086584 | 0.79 | PIK3CA (0.54) | PIK3CGPIK3CAPIK3CDAXLCDK8 | |
| SCHEMBL28506118 | 0.76 | DYRK1A (0.51) | MAP4K1PIK3CGDYRK1APIK3CAPIK3CD | |
| SCHEMBL28502521 | 0.75 | DYRK1A (0.64) | PIK3CGDYRK1APIK3CAPIK3CDAXL | |
| SCHEMBL28502161 | 0.75 | BRD4 (0.64) | MAP4K1PIK3CGDYRK1APIK3CAPIK3CD | |
| SCHEMBL31344455 | 0.74 | MAP4K1 (0.68) | MAP4K1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |