Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.58 |
| ▸ | IL2 | P60568 | 3/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 7/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 8/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | INSR | P06213 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | SGK1 | O00141 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28499901 | 0.87 | MAP4K1 (0.61) | MAP4K1IL2MAP3K11DYRK1ATNIK | |
| SCHEMBL28506939 | 0.86 | MAP4K1 (0.47) | MAP4K1IL2MAP3K11DYRK1ATNIK | |
| SCHEMBL31536249 | 0.86 | MAP4K1 (0.47) | MAP4K1IL2MAP3K11DYRK1ATNIK | |
| SCHEMBL28513907 | 0.86 | ROCK2 (0.48) | MAP4K1IL2DYRK1ATNIKROCK2 | |
| SCHEMBL28504488 | 0.86 | MAP4K1 (0.59) | MAP4K1IL2MAP3K11DYRK1A | |
| SCHEMBL28499623 | 0.84 | CHEK1 (0.46) | MAP4K1IL2MAP3K11DYRK1ATNIK | |
| SCHEMBL21590290 | 0.84 | MAP4K1 (0.64) | MAP4K1IL2TNIK | |
| SCHEMBL28504384 | 0.82 | MAP4K1 (0.66) | MAP4K1IL2MAP3K11TNIKIKBKB | |
| SCHEMBL28506141 | 0.82 | MAP4K1 (0.46) | MAP4K1IL2MAP3K11DYRK1AABL1 | |
| SCHEMBL21592600 | 0.81 | MAP3K11 (0.66) | MAP4K1IL2MAP3K11DYRK1ATNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |