Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 3/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.44 |
| ▸ | GABRE | P78334 | 1/20 | 0.44 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.44 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.44 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15560997 | 0.91 | JAK1 (0.55) | JAK1PIK3CABRD4CDK9WNT3A | |
| SCHEMBL28499853 | 0.87 | PLK4 (0.45) | JAK1PIK3CACDK9CCNT1CDK7 | |
| SCHEMBL21590284 | 0.80 | JAK1 (0.43) | JAK1BRD4CDK9WNT3AGABRP | |
| SCHEMBL28507487 | 0.80 | MAP4K1 (0.51) | JAK1CDK9GABRPGABRDGABRA1 | |
| SCHEMBL20112166 | 0.79 | PDK4 (0.58) | JAK1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL15778686 | 0.78 | ESR2 (0.54) | JAK1PIK3CABTKCDK7CDK8 | |
| SCHEMBL15778894 | 0.78 | NR1H2 (0.53) | JAK1PIK3CABTKCDK7CDK8 | |
| SCHEMBL28906243 | 0.78 | HTR6 (0.42) | JAK1CDK9WNT3AGABRPGABRD | |
| SCHEMBL27025890 | 0.78 | GRM1 (0.51) | JAK1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL31198348 | 0.76 | BCL2 (0.58) | JAK1BRD4CDK9CYP11B2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |