Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GUCY1A1 | Q02108 | 17/20 | 0.41 |
| ▸ | GUCY1B1 | Q02153 | 17/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29379281 | 1.00 | ADORA3 (0.47) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL23186729 | 0.88 | ADORA3 (0.54) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL255841 | 0.87 | ADORA3 (0.63) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL29382316 | 0.87 | ADORA3 (0.49) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL23161945 | 0.86 | ADORA3 (0.51) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL12298802 | 0.84 | PDE5A (0.45) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL29637210 | 0.84 | ADORA3 (0.49) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL23161914 | 0.84 | ADORA3 (0.49) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL10064748 | 0.83 | ADORA3 (0.62) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL23161969 | 0.82 | ADORA3 (0.52) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108727340-B | Fluorine substituted indazoles and use thereof | 广东东阳光药业有限公司 | 2020-12-29 | — | — | CN | disclosed |