Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.48 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855473 | 0.87 | MAPT (0.71) | GRM5MAPTSMN1; SMN2POLBMEN1 | |
| SCHEMBL26673924 | 0.86 | GRM5 (0.64) | GRM5MAPTSMN1; SMN2NPC1TSHR | |
| SCHEMBL2856172 | 0.83 | MAPT (0.55) | GRM5MAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL26673920 | 0.81 | MAPT (0.71) | GRM5MAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL26674089 | 0.81 | MAPT (0.71) | GRM5MAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL26855978 | 0.80 | GRM5 (0.52) | GRM5MAPTSMN1; SMN2NPC1TSHR | |
| SCHEMBL26673874 | 0.80 | GRM5 (0.64) | GRM5MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL26673925 | 0.80 | GRM5 (0.64) | GRM5MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2858001 | 0.77 | GRM5 (0.70) | GRM5MAPTRAB9APOLBNTRK1 | |
| SCHEMBL2854538 | 0.76 | KDM4E (0.53) | GRM5MAPTSMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |