Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | JAK1 | P23458 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.50 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.50 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2852141 | 0.86 | JAK2 (0.56) | JAK2JAK1GRM5KCNJ6KCNJ3 | |
| SCHEMBL2854953 | 0.82 | SMN1; SMN2 (0.50) | KDM4EJAK2JAK1SMN1; SMN2MEN1 | |
| SCHEMBL14107734 | 0.81 | PIK3CD (0.53) | JAK2JAK1ADCY1KDM1APIK3CD | |
| SCHEMBL28889677 | 0.78 | KDM4E (0.55) | KDM4EGRM5SMN1; SMN2MEN1KMT2A | |
| SCHEMBL30153356 | 0.78 | KDM4E (0.55) | KDM4EGRM5ADCY1SMN1; SMN2MEN1 | |
| SCHEMBL28401280 | 0.78 | KDM4E (0.55) | KDM4EGRM5ADCY1SMN1; SMN2MEN1 | |
| SCHEMBL4640994 | 0.77 | LCK (0.52) | JAK2JAK1GRM5KDM1APIK3CD | |
| SCHEMBL2850356 | 0.76 | GRM5 (0.60) | KDM4EGRM5SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31703858 | 0.76 | JAK2 (0.47) | JAK2JAK1PIK3CD | |
| SCHEMBL30881746 | 0.75 | HTR1A (0.48) | KDM4EGRM5ADCY1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |