Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.54 |
| ▸ | IL2 | P60568 | 4/20 | 0.54 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28504703 | 0.94 | MAP4K1 (0.54) | MAP4K1IL2MAP3K11SGK1CAMKK2 | |
| SCHEMBL21592886 | 0.91 | TNIK (0.54) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592637 | 0.83 | MAP4K1 (0.59) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL28511448 | 0.81 | MAP4K1 (0.63) | MAP4K1IL2NEK1MAP3K11SGK1 | |
| SCHEMBL21592687 | 0.80 | KIT (0.62) | MAP4K1IL2MAP3K11KIT | |
| SCHEMBL21592829 | 0.80 | MAP4K1 (0.56) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592915 | 0.79 | MAP4K1 (0.54) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592726 | 0.78 | MAP4K1 (0.65) | MAP4K1IL2MAP3K11KITDYRK1A | |
| SCHEMBL21592692 | 0.78 | MAP4K1 (0.53) | MAP4K1IL2MAP3K11KIT | |
| SCHEMBL21592870 | 0.77 | MAP4K1 (0.59) | MAP4K1IL2KITDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |