Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21590311 | 1.00 | CDK4 (0.43) | CDK4CCND1HDAC1HDAC6HDAC3 | |
| SCHEMBL21590160 | 1.00 | CDK4 (0.43) | CDK4CCND1HDAC1HDAC6HDAC3 | |
| SCHEMBL14817948 | 0.84 | MMP13 (0.44) | CDK4CCND1LMNARAB9ACES2 | |
| SCHEMBL30644814 | 0.82 | KMT2A (0.49) | CDK4CCND1HDAC1HDAC6RAB9A | |
| SCHEMBL29845593 | 0.82 | KMT2A (0.49) | CDK4CCND1HDAC1HDAC6RAB9A | |
| SCHEMBL22859164 | 0.80 | UTS2R (0.41) | MAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL22859166 | 0.80 | UTS2R (0.41) | MAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL22859153 | 0.80 | UTS2R (0.41) | MAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL12101326 | 0.78 | HDAC4 (0.47) | CDK4CCND1HDAC1HDAC6HDAC3 | |
| SCHEMBL6034132 | 0.75 | CDK4 (0.51) | CDK4CCND1HDAC1HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112239473-B | Process for preparing tricyclic compounds as HPK1 inhibitors | 百济神州(北京)生物科技有限公司 | 2023-12-08 | — | — | CN | disclosed |
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |