Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 13/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | RPA1 | P27694 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18693255 | 0.88 | PPARA (0.62) | PPARAPPARGKDM4EALDH1A1MEN1 | |
| SCHEMBL18693557 | 0.86 | ALDH1A1 (0.49) | PPARAPPARGKDM4EALDH1A1MEN1 | |
| SCHEMBL18717636 | 0.80 | PPARA (0.52) | PPARAPPARGKDM4EALDH1A1MEN1 | |
| SCHEMBL18717625 | 0.79 | CFTR (0.50) | PPARAPPARGKDM4EALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL18692343 | 0.78 | CFTR (0.49) | PPARAPPARGKDM4EALDH1A1MEN1 | |
| SCHEMBL18694504 | 0.75 | CFTR (0.53) | PPARAPPARGKDM4EALDH1A1MEN1 | |
| SCHEMBL18692867 | 0.75 | ALDH1A1 (0.48) | PPARAPPARGKDM4EALDH1A1MEN1 | |
| SCHEMBL18692216 | 0.74 | CFTR (0.52) | PPARAPPARGKDM4EALDH1A1MEN1 | |
| SCHEMBL18694488 | 0.73 | CFTR (0.49) | PPARAPPARGKDM4EALDH1A1MEN1 | |
| SCHEMBL18874664 | 0.73 | PPARA (1.00) | PPARAPPARGMAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108513574-B | N-sulfonylated pyrazolo [3, 4-b ] pyridine-6-carboxamides and methods of use | 艾伯维公司 | 2021-01-05 | — | — | CN | disclosed |