Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 12/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 12/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14651915 | 0.98 | NTRK1 (0.38) | NTRK1CSNK2A2CSNK2A1FGFR1NTRK2 | |
| SCHEMBL19279707 | 0.86 | CSNK2A2 (0.39) | NTRK1CSNK2A2CSNK2A1FGFR1PIK3CD | |
| SCHEMBL21199390 | 0.85 | CSNK2A2 (0.40) | NTRK1CSNK2A2CSNK2A1NTRK2ACVRL1 | |
| SCHEMBL13869069 | 0.81 | RXFP1 (0.34) | KDM4E | |
| SCHEMBL12537596 | 0.81 | NTRK1 (0.41) | NTRK1CSNK2A2CSNK2A1FGFR1NTRK2 | |
| SCHEMBL12283438 | 0.80 | NTRK1 (0.38) | NTRK1CSNK2A2CSNK2A1FGFR1NTRK2 | |
| SCHEMBL12285417 | 0.78 | KDM4E (0.45) | CSNK2A2CSNK2A1KDM4E | |
| SCHEMBL12283330 | 0.77 | CSNK2A2 (0.43) | NTRK1CSNK2A2CSNK2A1FGFR1PIK3CD | |
| SCHEMBL19279752 | 0.77 | CSNK2A2 (0.35) | NTRK1CSNK2A2CSNK2A1NTRK2PIK3CD | |
| SCHEMBL12537481 | 0.76 | NTRK1 (0.51) | NTRK1CSNK2A2CSNK2A1NTRK2TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112262139-B | Aminopyrrolotriazines as kinase inhibitors | 百时美施贵宝公司 | 2023-07-25 | — | — | CN | disclosed |
| CN-112262139-A | Aminopyrrolotriazines as kinase inhibitors | 百时美施贵宝公司 | 2021-01-22 | — | — | CN | disclosed |