Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 12/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 12/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14651915 | 0.81 | NTRK1 (0.38) | NTRK1CSNK2A2CSNK2A1FGFR1NTRK2 | |
| SCHEMBL27315108 | 0.79 | NTRK1 (0.57) | NTRK1CSNK2A2CSNK2A1FGFR1NTRK2 | |
| SCHEMBL12283372 | 0.76 | CSNK2A2 (0.53) | CSNK2A2CSNK2A1ACVRL1PIK3CD | |
| SCHEMBL12284245 | 0.75 | CSNK2A2 (0.68) | CSNK2A2CSNK2A1ACVRL1 | |
| SCHEMBL27315133 | 0.75 | ACVRL1 (0.45) | CSNK2A2CSNK2A1ACVRL1TNK2PIK3CD | |
| SCHEMBL12283230 | 0.70 | CSNK2A2 (0.67) | CSNK2A2CSNK2A1 | |
| SCHEMBL19377773 | 0.70 | PIK3CD (0.38) | NTRK1CSNK2A2CSNK2A1FGFR1NTRK2 | |
| SCHEMBL30334336 | 0.70 | CSNK2A2 (0.36) | NTRK1CSNK2A2CSNK2A1NTRK2PIK3CD | |
| SCHEMBL13625183 | 0.70 | FGFR1 (0.42) | NTRK1CSNK2A2CSNK2A1FGFR1NTRK2 | |
| SCHEMBL19279707 | 0.69 | CSNK2A2 (0.39) | NTRK1CSNK2A2CSNK2A1FGFR1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011123493-A1 | SUBSTITUTED PYRROLOTRIAZINES AS PROTEIN KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-06 | — | — | WO | disclosed |