Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377003 | 1.00 | POLB (0.43) | POLBKAT2BMEN1KMT2AROCK2 | |
| SCHEMBL17571721 | 0.82 | CA1 (0.48) | KAT2BMEN1KMT2AROCK2ALDH1A1 | |
| SCHEMBL21360220 | 0.81 | POLB (0.47) | POLBMEN1KMT2AALDH1A1CA1 | |
| SCHEMBL19397755 | 0.79 | KAT2B (0.46) | KAT2BMEN1KMT2AROCK2ALDH1A1 | |
| SCHEMBL19402461 | 0.79 | KAT2B (0.52) | KAT2BROCK2ALDH1A1CA1CA2 | |
| SCHEMBL28505889 | 0.79 | KAT2B (0.46) | KAT2BROCK2ALDH1A1CA1CA2 | |
| SCHEMBL17571687 | 0.79 | KAT2B (0.46) | KAT2BROCK2ALDH1A1CA1CA2 | |
| SCHEMBL17007854 | 0.79 | POLB (0.50) | POLBMEN1KMT2AALDH1A1CA1 | |
| SCHEMBL19397772 | 0.77 | KAT2B (0.50) | KAT2BROCK2ALDH1A1CA1CA2 | |
| SCHEMBL17559144 | 0.74 | ACHE (0.33) | KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107074824-B | Phthalazine derivatives of formula (I) as PCAF and GCN5 inhibitors for the treatment of cancer | 基因泰克公司 | 2021-01-08 | — | — | CN | disclosed |